Yes! LightStep is designed to handle truly end-to-end transactions from the end-user button clicks down to database queries. LightStep is based on the OpenTracing open standard and specifically intended to work across heterogeneous system architectures. See the Quickstart with LightStep [𝑥]PM documentation for platform-specific SDK support.
LightStep's architecture handles unlimited cardinality which is particularly useful in the case of mobile platform where the number of unique devices, users, locations, and other important tag information can easily reach high orders of magnitude. To increase your confidence that LightStep will scale to meet the needs of your system's traffic, see LightStep's case study with Lyft.
Mobile use cases also lend themselves to setting up Streams for common segmentations such as device type, application version, and geographical region that may show different performance characteristics across segments. Check out the Explorer Latency Histogram for ways to use LightStep to identify important segmentations in your system performance.